Immunostimulatory Activities of the Sulfated Polysaccharide Ascophyllan from Ascophyllum nodosum in in Vivo and in Vitro Systems

Kiyoaki NAKANO; Daekyung KIM; Zedong JIANG; Mikinori UENO; Takasi OKIMURA; Kenichi YAMAGUCHI; Tatsuya ODA

doi:10.1271/bbb.120232

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Immunostimulatory Activities of the Sulfated Polysaccharide Ascophyllan from Ascophyllum nodosum in in Vivo and in Vitro Systems

Kiyoaki NAKANO, Daekyung KIM, Zedong JIANG, Mikinori UENO, Takasi OKIMURA, Kenichi YAMAGUCHI, Tatsuya ODA

著者情報

キーワード: Ascophyllum nodosum, ascophyllan, natural killer activity, macrophages, nitric oxide

ジャーナルフリー早期公開

論文ID: 120232

DOI https://doi.org/10.1271/bbb.120232

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 8 p.1573

詳細

抄録

Splenic natural killer (NK) cell activity against YAC-1 cells increased in mice intraperitoneally injected with ascophyllan. Ascophyllan enhanced the cytotoxicity of RAW264.7 cells toward YAC-1 cells in a concentration-dependent manner. The cytotoxicity of ascophyllan-stimulated RAW264.7 cells as to YAC-1 cells was suppressed with N^G-nitro-L-argininemethylester hydrochloride (L-NAME), an inhibitor of nitric oxide (NO) synthase, suggesting the involvement of NO in the cytotoxicity of ascophyllan-stimulated RAW264.7 cells.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）