Human MDR1 and MRP1 Recognize Berberine as Their Transport Substrate

Nobukazu SHITAN; Miyako TANAKA; Koichiro TERAI; Kazumitsu UEDA; Kazufumi YAZAKI

doi:10.1271/bbb.60441

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Human MDR1 and MRP1 Recognize Berberine as Their Transport Substrate

Nobukazu SHITAN, Miyako TANAKA, Koichiro TERAI, Kazumitsu UEDA, Kazufumi YAZAKI

著者情報

キーワード: ATP-binding cassette (ABC) transporter, berberine, multidrug resistance protein (MDR), multidrug resistance-associated protein (MRP), transport

ジャーナルフリー早期公開

論文ID: 60441

DOI https://doi.org/10.1271/bbb.60441

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 1 p.242

詳細

抄録

To examine whether human ATP-binding cassette (ABC) transporters play a role in the detoxification of plant alkaloid berberine, we investigated berberine transport using multidrug resistance protein1 (MDR1) and multidrug resistance-associated protein1 (MRP1). Cells expressing MDR1 or MRP1 accumulated less berberine. Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate.

責任著者(Corresponding author)

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