Synthesis of Lipid Derivatives of Pyrrole Polyamide and Their Biological Activity

Masahiko YAMAMOTO; Changjin ZHU; Lui YI; Zheng RONG; Yoshie MIURA; Minoru IZUMI; Shuhei NAKAJIMA; Ken-ichi TANAMOTO; Sakayu SHIMIZU; Naomichi BABA

doi:10.1271/bbb.60650

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Synthesis of Lipid Derivatives of Pyrrole Polyamide and Their Biological Activity

Masahiko YAMAMOTO, Changjin ZHU, Lui YI, Zheng RONG, Yoshie MIURA, Minoru IZUMI, Shuhei NAKAJIMA, Ken-ichi TANAMOTO, Sakayu SHIMIZU, Naomichi BABA

著者情報

キーワード: pyrrole polyamide, lipid, phospholipid, cancer cell, human immunodeficiency virus (HIV)-II

ジャーナルフリー早期公開

論文ID: 60650

DOI https://doi.org/10.1271/bbb.60650

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 4 p.1078

詳細

抄録

Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

責任著者(Corresponding author)

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