mRNA Expression of Lysyl Oxidase and Matrix Metalloproteinase-12 in Mouse Skin

Yurika MIZOBE; Daichi OIKAWA; Shoichiro TSUYAMA; Yoriko AKIMOTO; Kousuke HAMASU; Eiichiro ONITSUKA; Mikako SATO; Yoshihisa TAKAHATA; Fumiki MORIMATSU; Mitsuhiro FURUSE

doi:10.1271/bbb.80450

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mRNA Expression of Lysyl Oxidase and Matrix Metalloproteinase-12 in Mouse Skin

Yurika MIZOBE, Daichi OIKAWA, Shoichiro TSUYAMA, Yoriko AKIMOTO, Kousuke HAMASU, Eiichiro ONITSUKA, Mikako SATO, Yoshihisa TAKAHATA, Fumiki MORIMATSU, Mitsuhiro FURUSE

著者情報

キーワード: elastic fiber, lysyl oxidase, matrix metalloproteinase-12, skin, mice

ジャーナルフリー早期公開

論文ID: 80450

DOI https://doi.org/10.1271/bbb.80450

この記事には本公開記事があります。

The final version of this article is now available: Vol. 72 (2008) , No. 11 p.3067

詳細

抄録

Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.

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