Pinostrobin from Boesenbergia pandurata Is an Inhibitor of Ca2+-Signal-Mediated Cell-Cycle Regulation in the Yeast Saccharomyces cerevisiae

Wachirasak WANGKANGWAN; Saipin BOONKERD; Warinthorn CHAVASIRI; Kasama SUKAPIROM; Kovit PATTANAPANYASAT; Ngampong KONGKATHIP; Tokichi MIYAKAWA; Chulee YOMPAKDEE

doi:10.1271/bbb.90114

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Pinostrobin from Boesenbergia pandurata Is an Inhibitor of Ca²⁺-Signal-Mediated Cell-Cycle Regulation in the Yeast Saccharomyces cerevisiae

Wachirasak WANGKANGWAN, Saipin BOONKERD, Warinthorn CHAVASIRI, Kasama SUKAPIROM, Kovit PATTANAPANYASAT, Ngampong KONGKATHIP, Tokichi MIYAKAWA, Chulee YOMPAKDEE

著者情報

キーワード: yeast based assay, Boesenbergia pandurata, pinostrobin, Ca²⁺ signal, inhibitor

ジャーナルフリー早期公開

論文ID: 90114

DOI https://doi.org/10.1271/bbb.90114

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2009) , No. 7 p.1679

詳細

抄録

Upon searching plant extracts for inhibitors of the Ca²⁺ signaling pathway using the zds1Δ-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca²⁺ signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae.

責任著者(Corresponding author)

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