総説
ナノ秒パルス高電界：生体作用機序と応用の可能性
キーワード:
nanosecond pulsed electric field,
electroporation,
stress response,
cell death induction,
neutrophil extracellular trap
2021 年 61 巻 3 号 p. 162-165
詳細
2021 年 61 巻 3 号 p. 162-165
Pulsed electric fields (PEFs) have been widely utilized in life sciences, particularly for electroporation. Recent advances in electrical engineering enable the use of ultrashort PEFs in duration of nanoseconds (referred to as nanosecond PEFs, nsPEFs). Unlike milli- to microsecond PEFs used for electroporation, nsPEFs does not generate membrane pores suited for macromolecule transfer. Instead, nsPEFs can elicit various cellular responses in an intensity-dependent manner. nsPEFs are increasingly recognized as a novel physical means with unique biological actions. This review provides an overview of cellular responses to nsPEFs and possible biomedical applications of nsPEFs.
