Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces

Shinya FUKIZAWA; Mai YAMASHITA; Shiho FUJISAKA; Kazuyuki TOBE; Yuji NONAKA; Norihito MURAYAMA

doi:10.12938/bmfh.2019-045

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Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces

Shinya FUKIZAWA, Mai YAMASHITA, Shiho FUJISAKA, Kazuyuki TOBE, Yuji NONAKA, Norihito MURAYAMA

著者情報

キーワード: metabolomics, amino acids, bile acids, feces, isoxanthohumol

ジャーナルオープンアクセス早期公開

論文ID: 2019-045

DOI https://doi.org/10.12938/bmfh.2019-045

この記事には本公開記事があります。

The final version of this article is now available: Vol. 39 (2020), No. 3 pp. 100-108

詳細

抄録

The aim of this study was to verify the effect of treatment with isoxanthohumol (IX) on the metabolomics profile of mouse feces to explore the host-intestinal bacterial interactions at the molecular level. The fecal contents of several amino acids in the high-fat diet (HFD) + 0.1% IX group (treated with IX mixed in diets for 12 weeks) were significantly lower than in the HFD group. The fecal contents of the secondary bile acid deoxycholic acid (DCA) in the HFD + 180 mg/kg IX group (orally treated with IX for 8 weeks) were significantly lower than in the HFD group; the values in the HFD group were higher than those in the normal diet (ND) group. Administration of IX changed the fecal metabolomics profile. For some metabolites, IX normalized HFD-induced fluctuations.

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