Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Inhibitory Activities of (−)-Epigallocatechin-3-O-gallate against Topoisomerases I and II
Keitarou SUZUKIShoji YAHARAFumio HASHIMOTOMasaru UYEDA
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2001 Volume 24 Issue 9 Pages 1088-1090

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Abstract

The substitution of gallic acid at the 3 position of (−)-epigallocatechin-3-O-gallate (EGCG) increased the inhibition against topoisomerase I from calf thymus gland and topoisomerase II from human placenta, and the substitution of a hydroxyl group at the 3' position increased the inhibition against the topoisomerase I. These results suggested that the 3 and 3' positions of the EGCG molecule play important roles in the process of inhibition of topoisomerases I and II. EGCG showed strong inhibition against topoisomerases I from wheat germ, calf thymus gland and Vero cells, and showed weak or no inhibition against topoisomerases I from carcinoma cells such as A549, HeLa and COLO 201 cells. EGCG differentially inhibited the topoisomerases I from different sources.

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© 2001 The Pharmaceutical Society of Japan
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