Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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In Vitro Susceptibility of Four Serotypes of Enterohaemorrhagic Escherichia coli to Antimicrobial Agents
Shigeharu OieMasatada KawakamiAkira KamiyaMasaaki Tomita
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2002 年 25 巻 5 号 p. 671-673

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We evaluated the in vitro susceptibility of four serotypes of enterohaemorrhagic Escherichia coli (E. coli O26, E. coli O111, E. coli O157, and E. coli O165) with diverse DNA patterns to antimicrobial agents. The minimum inhibitory concentrations (MIC) determined in a total of 83 strains using Mueller–Hinton agar under aerobic and anaerobic conditions were 0.015—0.12 μg/ml for ciprofloxacin, 0.06—1 μg/ml for norfloxacin, 2—64 μg/ml for fosfomycin without glucose-6-phosphate (G-6-P), 0.25—32 μg/ml for fosfomycin with G-6-P, 2—256 μg/ml for kanamycin, 0.125—2 μg/ml for cefoperazone, and 0.06—1 μg/ml for ceftazidime. The MIC of ciprofloxacin, norfloxacin, cefoperazone, and ceftazidime were low in all strains examined.
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© 2002 The Pharmaceutical Society of Japan
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