Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Trypanocidal Constituents in Plants 3.
Leaves of Garcinia intermedia and Heartwood of Calophyllum brasiliense
Fumiko AbeShinya NagafujiHikaru OkabeHiroshige AkahaneElizabeth Estrada-MuñizMaira Huerta-ReyesRicardo Reyes-Chilpa
ジャーナル フリー

2004 年 27 巻 1 号 p. 141-143


The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison.

© 2004 The Pharmaceutical Society of Japan
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