Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents

Hideaki Matsuda; Yoshiko Kawaguchi; Miho Yamazaki; Noriko Hirata; Shunsuke Naruto; Yusuke Asanuma; Takayuki Kaihatsu; Michinori Kubo

doi:10.1248/bpb.27.1611

Regular Articles

Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents

Hideaki Matsuda, Yoshiko Kawaguchi, Miho Yamazaki, Noriko Hirata, Shunsuke Naruto, Yusuke Asanuma, Takayuki Kaihatsu, Michinori Kubo

著者情報

キーワード: Piper nigrum, cubebin, 3,4-dimethoxy-3,4-desmethylenedioxycubebin, 3-desmethoxycubebinin, murine B16 melanoma cell, stimulatory effect on melanogenesis

ジャーナルフリー

2004 年 27 巻 10 号 p. 1611-1616

DOI https://doi.org/10.1248/bpb.27.1611

詳細

抄録

A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells. Activity-guided fractionation of the methanolic extract led to the isolation of two known lignans, (−)-cubebin (1) and (−)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), together with a new lignan, (−)-3-desmethoxycubebinin (3). Among these lignans, 1 and 2 showed a significant stimulatory activity of melanogenesis without any significant effects on cell proliferation.

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