ABSORPTION OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (rhG-CSP) AND BLOOD LEUKOCYTE DYNAMICS FOLLOWING INTRANASAL ADMINISTRATION IN RABBITS

Yoshiteru WATANABE; Yoshiaki MATSUMOTO; Miho YAMAGUCHI; Rie KIKUCHI; Kazuo TAKAYAMA; Hideaki NOMURA; Kazutoshi MARUYAMA; Mitsuo MATSUMOTO

doi:10.1248/bpb.16.93

渡辺善照, 松本宜明, 山口美穂, 菊地利恵, 高山和郎, 野村英昭, 丸山和俊, 松本光雄

著者情報

キーワード: granulocyte colony-stimulating factor, nasal absorption, dimethyl-β-cyclodextrin, serum rhG-CSF level, blood total leukocyte number

ジャーナルフリー

1993 年 16 巻 1 号 p. 93-95

DOI https://doi.org/10.1248/bpb.16.93

詳細

抄録

Absorption of recombinant human granulocyte colony-stimulating factors (rhG-CSF) following intranasal administration of aqueous preparations containing rhG-CSF with or without dimethyl-β-cyclodextrin was investigated. It was found that rhG-CSF was absorbed and the total leukocyte numbers in peripheral blood markedly increased after intranasal instillation of rhG-CSF solution (pH 4) without excipients. Simultaneously administered dimethyl-β-cyclodextrin enhanced nasal absorption of rhG-CSF. Consequently, serum rhG-CSF concentrations and total leukocyte numbers were greatly increased.

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