AUTOOXIDATION OF ALKYLHYDRAZONES AND MUTAGENICITY OF THE RESULTING HYDROPEROXIDES

Masataka MOCHIZUKI; Kozo MICHIHIRO; Katsuko SHIOMI; Kei ITOH; Yoshiko TANGE; Shoji HIZATATE

doi:10.1248/bpb.16.96

望月正隆, 道廣幸三, 塩見佳津子, 伊藤啓, 丹下佳子, 膝舘祥治

著者情報

キーワード: alkylhydrazone, mutagenicity, autooxidation, hydroperoxide, alkylation, hydroxyl radical

ジャーナルフリー

1993 年 16 巻 1 号 p. 96-98

DOI https://doi.org/10.1248/bpb.16.96

詳細

抄録

Acetone alkylhydrazones were readily autooxidized to 2-alkylazo-2-propyl hydroperoxides, which were directly mutagenic in Salmonella typhimurium TA1535, TA100, TA102 and Escherichia coli WP2hcr^-. The mechanism of this mutagenicity presumes that the hydroperoxides in aqueous solution decompose to alkyl diazonium ions which were observed in the alkylation of 4-(p-nitrobenzyl)pyridine, and also to hydroxyl radical which was detected by ESR.

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