Inhibition of DNA of Topoisomerase I Activity by Diethylstilbestrol and Its Analogues

Taiko ODA; Yoshihiro SATO; Masahiko KODAMA; Motohisa KANEKO

doi:10.1248/bpb.16.708

小田泰子, 佐藤良博, 児玉昌彦, 金子元久

著者情報

キーワード: diethylstilbestrol, indenestrol, DNA topoisomerase, dienestrol, Chinese hamster V79 cell

ジャーナルフリー

1993 年 16 巻 7 号 p. 708-710

DOI https://doi.org/10.1248/bpb.16.708

詳細

抄録

Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (±)-indenestrol B, (±)-IB, showed the strongest inhibitory effect.

責任著者(Corresponding author)

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