Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
ENHANCEMENT OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR NECROSIS FACTOR α PRODUCTION BY PHENETHYLPHTHALIMIDE ANALOGS
佐崎 敬三柴田 芳宏西村 幸治橋本 祐一岩崎 成夫
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1994 年 17 巻 9 号 p. 1313-1315

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Effects of phenyl-, benzyl-, phenethyl-, and phenylpropylphthalimides on 12-O-tetra-decanoylphorbol-13-acetate (TPA)-induced tumor necrosis factor (TNF)-α production by human leukemia cell line HL-60 were examined. Among the four phthalimide derivatives, only phenethylphthalimide showed potent enhancing effect on TNF-α production.

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