COLUMBIN ISOLATED FROM CALUMBAE RADIX AFFECTS THE SLEEPING TIME OF ANESTHETIZED MICE

Keiji WADA; Toshiyuki KURIHARA; Masaaki YAGI; Ryu KOBAYASHI; Hidetoshi KAMINAGA; Koji TOI; Masanobu HAGA

doi:10.1248/bpb.18.634

Keiji WADA, Toshiyuki KURIHARA, Masaaki YAGI, Ryu KOBAYASHI, Hidetoshi KAMINAGA, Koji TOI, Masanobu HAGA

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Keywords: columbin, anesthetic, sleeping time, urethane, hexobarbital

JOURNAL FREE ACCESS

1995 Volume 18 Issue 4 Pages 634-636

DOI https://doi.org/10.1248/bpb.18.634

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Abstract

In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and α-chloralose mixture and prolonged the sleeping time induced by hexobarbital in mice.

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