Anti-HIV-1 Activity of Herbs in Labiatae

Katsuhiro YAMASAKI; Masami NAKANO; Takuya KAWAHATA; Haruyo MORI; Toru OTAKE; Noboru UEDA; Isao OISHI; Rie INAMI; Megumi YAMANE; Miki NAKAMURA; Hiroko MURATA; Tsutomu NAKANISHI

doi:10.1248/bpb.21.829

Katsuhiro YAMASAKI, Masami NAKANO, Takuya KAWAHATA, Haruyo MORI, Toru OTAKE, Noboru UEDA, Isao OISHI, Rie INAMI, Megumi YAMANE, Miki NAKAMURA, Hiroko MURATA, Tsutomu NAKANISHI

著者情報

キーワード: HIV-1, antiviral activity, Labiatae, Melissa officinalis, Ocimum basilicum cv "cinnamon", Perilla frutescens var. crispa f. viridis

ジャーナルフリー

1998 年 21 巻 8 号 p. 829-833

DOI https://doi.org/10.1248/bpb.21.829

詳細

抄録

The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro. Forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against HIV-1 induced cytopathogenicity in MT-4 cells. In particular, the aqueous extracts of Melissa officinalis, a family of Mentha×piperita "grapefruit mint", Mentha×piperita var. crispa, Ocimum basilicum cv "cinnamon", Perilla frutescens var. crispa f.viridis, Prunella vulgaris subsp. asiatica and Satureja montana showed potent anti-HIV-1 activity (with an ED of 16μg/ml). The active components in the extract samples were found to be water-solubel polar substances, not nonpolar compounds such as essential oils. In addition, these aqueous extracts inhibited giant cell formation in co-culture of Molt-4 cels with and without HIV-1 infection and showed inhibitory activity against HIV-1 reverse transcriptase.

責任著者(Corresponding author)

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