Polulation Pharmacokinetic Analysis of Mexiletine in Adult Arrhythmic Patients in Japanese Population

抄録

We analyzed mexiletine in Japanese patients using populaiton pharmacokinetics. 139 serum concentration data, which were collected for therapeutic drug monitoring from 121 patients, were used for this analysis. We also investigated influence of age and gender on pharmacokinetics, and age was found to be an influential factor on clearance. The final pharmacokinetic parameters are, CL/F=0.580-0.00369·AGE (l/h/kg) and V_d/F=6.63 (L/kg). These results shoulds be useful for adjusting the dosage to a patient's age for the prevention of an adverse reaction caused by overexposure.