Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Fas-Mediated Apoptosis is Enhanced by Glycyrrhizin without Alteration of Caspase-3-Like Activity
Shunji ISHIWATAKei NAKASHITAYasuko OZAWAMasahiro NIIZEKISeishiro NOZAKIYoshihisa TOMIOKAMichinao MIZUGAKI
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1999 年 22 巻 11 号 p. 1163-1166

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We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis. The enhancement effect of Fas-mediated apoptosis by GL was dose-dependent above 0.3 μM. Time course study revealed that simultaneous co-treatment of GL and anti-Fas antibody was crucial for the enhancement of apoptosis and pretreatment with GL was not effective. Anti-Fas antibody elicited caspase-3-like activity. However caspase-3-like activity with co-treatment of GL and anti-Fas antibody was the same level as the antibody alone. Glycyrrhetic acid, the aglycon of GL, did not enhance Fas-mediated apoptosis. The amphipathic property of GL might enable it to interact with the plasma membrance and lead to the enhancement of apoptosis.

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© The Pharmaceutical Society of Japan
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