Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Effects of Sulfhydryl Compounds on Interleukin-1-Induced Vasucular Endothelial Growth Factor Production in Human Synovial Stromal Cells
Fumio TSUJIHidehito MATSUOKAHiroyuki AONOMiwa TAKAIMasato HORIUCHIKazuo NISHIMURAShiro MITA
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2000 年 23 巻 5 号 p. 663-665

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We investigated the effects of various sulfhydryl compounds on interleukin-1 (IL-1)-induced vasucular endothelial growth factor (VEGF) production in human synovial stromal cells (HSSC). HSSC stimulated by IL-1β(100 ng/ml) produced VEGF and interleukin-6 (IL-6) in vitro. Monosulfhydryl compounds, N-acetylcysteine, D-penicillamine, tiopronin and the bucillamine-like disulfhydryl compound, compound A scarcely affected VEGF or IL-6 production at concentraitons of 10-5 and 10-4M. However, the disulfhydryl compound, budillamine in hibited VEGF production but not IL-6 production at concentrations of 10-5 and 10-4M. These results suggest that bucillamine may be a selective inhibitor of IL-1-induced VEGF production in HSSC, and that inhibition of VEGF production may require not only SH groups but also a specific chemical structure.

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