総説
A Systematic Review of the Zinc Content of the Hyperplastic Human Prostate Gland
2021 年 31 巻 3 号 p. 98-116
詳細
2021 年 31 巻 3 号 p. 98-116
Background: In many studies it was found that the Zn level in prostatic tissue plays an important role in etiology benign prostate hypertrophy (BPH) and its measurement may be useful as a biomarker for differential diagnosis of hyperplastic and malignant transformations of gland. These findings promoted more detailed studies of the Zn content in the prostatic tissue of subjects with BPH.
Method: The present study evaluated by systematic analysis the published data for Zn content analyzed in hyperplastic prostates as well as in normal glands. This evaluation reviewed 1885 studies, all of which were published in the years from 1921 to 2019 and were located by searching the databases Scopus, PubMed, MEDLINE, ELSEVIER-EMBASE, Cochrane Library, and the Web of Science. The articles were analyzed and “Median of Means” and “Range of Means” were used to examine heterogeneity of the measured Zn content in prostates of men with BPH and in prostates of apparently healthy adult subjects (control group). The objective analysis was performed on data from the 56 studies, with 1559 subjects for the BPH group and from the 97 studies, with 2985 subjects for the control group.
Results: It was found that the range of means of prostatic Zn content reported in the literature varies widely: for hyperplastic gland from 11 mg/kg to 760 mg/kg with median of means 178 mg/kg and for normal prostates of adults from 17 mg/kg to 547 mg/kg with median of means 132 mg/kg on a wet mass basis. Ratios of means of Zn content in hyperplastic prostate (ZnBPH) to Zn content in normal gland (ZnN), obtained by the same authors and methods, were calculated. It was shown that the range of means of ZnBPH/ZnN ratio varies from 0.35 to 5.98 with median of means 1.38.
Conclusion: Because of the uncertainties we have outlined, we recommend other primary studies should be performed.
