Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Rapid Communications
Per-Vessel Level Analysis of Fractional Flow Reserve and Instantaneous Wave-Free Ratio Discordance　― Insights From the AJIP Registry ―
Takayuki Warisawa, Christopher M. Cook, Henry Seligman, James P. Howard, Yousif Ahmad, Christopher Rajkumar, Shunichi Doi, Masafumi Nakayama, Toru Tanigaki, Hiroyuki Omori, Akihiro Nakajima, Futoshi Yamanaka, Sonoka Goto, Yohei Yakuta, Kenichi Karube, Teruyoshi Uetani, Yuetsu Kikuta, Yasutsugu Shiono, Yoshiaki Kawase, Hidetaka Nishina, Sunao Nakamura, Javier Escaned, Yoshihiro J. Akashi, Hitoshi Matsuo, Justin E. Davies
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キーワード: Diffuse disease, Fractional flow reserve, Instantaneous wave-free ratio
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2020 年 84 巻 6 号 p. 1034-1038

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Background:The per-vessel level impact of physiological pattern of disease on the discordance between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) has not been clarified.

Methods and Results:Using the AJIP registry, vessels with FFR/iFR discordance (133/671 [19.8%]) were analyzed. In the left anterior descending artery (LAD), physiologically diffuse disease, as assessed by pressure-wire pullback, was associated with FFR−/iFR+ (83.3% [40/48]), while physiologically focal disease was associated with FFR+/iFR− (57.4% [31/54]), significantly (P<0.0001). These differences were not significant in non-LAD (P=0.17).

Conclusions:The impact of physiological pattern of disease on FFR/iFR discordance is more pronounced in the LAD.

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日本循環器病學

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