Multisystem Inflammatory Syndrome in Children　― A New Syndrome Complicated With Acute Heart Failure Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection ―

Momoko Uchida; Yuichiro Kashima; Katsunori Mochizuki; Hiroto Sakamoto; Kotaro Mori; Soichiro Ebisawa; Kanako Takeshige; Kenichi Nitta; Koichiro Kuwahara; Hiroshi Imamura

doi:10.1253/circj.CJ-21-0243

Rapid Communications

Multisystem Inflammatory Syndrome in Children　― A New Syndrome Complicated With Acute Heart Failure Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection ―

Momoko Uchida, Yuichiro Kashima, Katsunori Mochizuki, Hiroto Sakamoto, Kotaro Mori, Soichiro Ebisawa, Kanako Takeshige, Kenichi Nitta, Koichiro Kuwahara, Hiroshi Imamura

Author information

Momoko Uchida
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine [Japan]
Yuichiro Kashima
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine [Japan]
Katsunori Mochizuki
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine [Japan]
Hiroto Sakamoto
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine [Japan]
Kotaro Mori
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine [Japan]
Soichiro Ebisawa
Department of Cardiology, Shinshu University School of Medicine [Japan]
Kanako Takeshige
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine [Japan]
Kenichi Nitta
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine [Japan]
Koichiro Kuwahara
Department of Cardiology, Shinshu University School of Medicine [Japan]
Hiroshi Imamura
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine [Japan]

Keywords: Multisystem inflammatory syndrome in children (MIS-C), Myocarditis, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

JOURNAL OPEN ACCESS FULL-TEXT HTML

2021 Volume 85 Issue 6 Pages 948-952

DOI https://doi.org/10.1253/circj.CJ-21-0243

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Abstract

Background:Multisystem inflammatory syndrome in children (MIS-C) is a rare syndrome temporally related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MIS-C shares similarities with Kawasaki disease, but left ventricular dysfunction is more common in MIS-C.

Methods and Results:This study reports the case of a 16-year-old Japanese male patient with MIS-C. Although the initial presentation was severe with circulatory and respiratory failure, the patient recovered completely. Endomyocardial biopsy showed active myocarditis with fibrosis. Immunoglobulin treatment was useful for recovery.

Conclusions:This is the first reported case of MIS-C in Japan. Cardiologists should be aware of MIS-C, a new disease, occurring during the global SARS-CoV-2 pandemic.

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