Abstract
We investigated the effect of mirin intake on the excretion of 8-OHdG. Mirin was concentrated at 90°C to half the original amount. The 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity of the concentrated mirin was 7 times as high that of the original mirin. Nine healthy adults were given 60 ml/day of concentrated mirin for seven days. A marked reduction in the mean urinary level of 8-OHdG was apparent by mirin intake: the mean urinary level of 8-OHdG before mirin intake was 9.5ng/mg of CRE and 7.4 ng/mg of CRE after mirin intake. This result suggests that concentrated mirin intake can reduce the level of oxidative DNA damage.
