Synthesis of cis- and trans-5,8-Dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone

Shiho ARIMA; Yaeko YAMADA (KONDA); Kazuyoshi TAKEDA; Hiroaki TAKAYANAGI; Yoshihiro HARIGAYA

doi:10.1248/cpb.49.1340

Notes

Synthesis of cis- and trans-5,8-Dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone

Shiho ARIMA, Yaeko YAMADA (KONDA), Kazuyoshi TAKEDA, Hiroaki TAKAYANAGI, Yoshihiro HARIGAYA

著者情報

キーワード: naphthoquinone, spiroacetal-bridged compound, antitumor activity

ジャーナルフリー

2001 年 49 巻 10 号 p. 1340-1342

DOI https://doi.org/10.1248/cpb.49.1340

詳細

抄録

Cis- and trans-5,8-dihydroxy-5,6,7,8-tetrahydro-1,4-naphthoquinone (1a, 1b) were for the first time synthesized from 5,8-dihydroxy-1,4-naphthoquinone (naphthazazine) (6) as a starting material and racemic triol (3) was first synthesized from 7. The configuration of 1a was determined by X-ray analysis.

責任著者(Corresponding author)

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