New Hemisynthetic Manoyl Oxide Derivatives with Antimicrobial Activity

Eleftherios KALPOUTZAKIS; Nektarios ALIGIANNIS; Sofia MITAKU; Ioanna CHINOU; Catherine CHARVALA; Alexios-Leandros SKALTSOUNIS

doi:10.1248/cpb.49.814

Regular Articles

New Hemisynthetic Manoyl Oxide Derivatives with Antimicrobial Activity

Eleftherios KALPOUTZAKIS, Nektarios ALIGIANNIS, Sofia MITAKU, Ioanna CHINOU, Catherine CHARVALA, Alexios-Leandros SKALTSOUNIS

著者情報

キーワード: labdane-type diterpene, antimicrobial activity, manoyl oxide, Cistus creticus

ジャーナルフリー

2001 年 49 巻 7 号 p. 814-817

DOI https://doi.org/10.1248/cpb.49.814

詳細

抄録

The synthesis and antimicrobial activity of ten labdane-type diterpenes derived from ent-3-β-hydroxy-13-epi-manoyl oxide (ribenol) is reported. The chloroethyl carbamidic ester 9 showed the strongest antimicrobial activity against all the tested gram (+), gram (−) bacteria and pathogenic fungi. Moreover, the glycoside 11 exhibited an interesting activity against the three tested fungi.

責任著者(Corresponding author)

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