Pyridazines. Part 31: Synthesis and Antiplatelet Activity of 4,5-Disubstituted-6-phenyl-3(2H)-pyridazinones

Eddy Sotelo; Nuria Fraiz; Matilde Yáñez; Reyes Laguna; Ernesto Cano; Enrique Raviña

doi:10.1248/cpb.50.1574

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Pyridazines. Part 31: Synthesis and Antiplatelet Activity of 4,5-Disubstituted-6-phenyl-3(2H)-pyridazinones

Eddy Sotelo, Nuria Fraiz, Matilde Yáñez, Reyes Laguna, Ernesto Cano, Enrique Raviña

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Keywords: pyridazinone, platelet, platelet aggregation, platelet aggregation inhibitor

JOURNAL FREE ACCESS

2002 Volume 50 Issue 12 Pages 1574-1577

DOI https://doi.org/10.1248/cpb.50.1574

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Abstract

This paper describes the synthesis and the antiplatelet activity of a series of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones. Some of these compounds show a dose-dependent activity and were found to be more active than their 5-substituted analogues.

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