Solvents Inducing Oxidation of Hydroxylamines

Shizuyo Horiyama; Kiyoko Suwa; Masae Yamaki; Hiromi Kataoka; Toyoshi Katagi; Mitsuo Takayama; Takae Takeuchi

doi:10.1248/cpb.50.996

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Solvents Inducing Oxidation of Hydroxylamines

Shizuyo Horiyama, Kiyoko Suwa, Masae Yamaki, Hiromi Kataoka, Toyoshi Katagi, Mitsuo Takayama, Takae Takeuchi

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Keywords: hydroxylamine, oxidation, LC-MS, NMR

JOURNAL FREE ACCESS

2002 Volume 50 Issue 7 Pages 996-1000

DOI https://doi.org/10.1248/cpb.50.996

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Abstract

Hydroxylamines gradually undergo oxidation to their oximes on being dissolved in organic solvent (e.g. methanol). This phenomenon was followed by ¹H-NMR and liquid chromatography-mass spectrometry (LC-MS). The oxidation rate was estimated from the peak area observed on the mass chromatogram at the protonated molecule or fragment ion on LC-atmospheric pressure chemical ionization (APCI)-MS. The results showed that the oxidation rate of hydroxylamines depended on the solvent type.

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