Improved Preparation of an Amino Acid Type Poly(Ethylene Glycol) Derivative

Keiko Hojo; Yuichi Susuki; Masahiko Sasaki; Mitsuko Maeda; Timothy John Smith; Koichi Kawasaki

doi:10.1248/cpb.50.1001

Notes

Improved Preparation of an Amino Acid Type Poly(Ethylene Glycol) Derivative

Keiko Hojo, Yuichi Susuki, Masahiko Sasaki, Mitsuko Maeda, Timothy John Smith, Koichi Kawasaki

Author information

Keywords: poly(ethylene glycol), hybrid, poly(ethylene glycol) hybrid, peptide hybrid, amino acid type poly(ethylene glycol)

JOURNAL FREE ACCESS

2002 Volume 50 Issue 7 Pages 1001-1003

DOI https://doi.org/10.1248/cpb.50.1001

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Abstract

An amino acid type poly(ethylene glycol) is a useful tool for preparation of a bi- or multivalent poly(ethylene glycol) hybrid of bioactive peptides, but synthesis is problematic. The amino acid type poly(ethylene glycol) was prepared from poly(oxyethylene)diglycolic acid followed by introduction of a fluorenylmethyloxycarbonyl group. The resulting product could be purified easily by LH-20 column chromatography and HPLC.

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