Efficient Synthesis of Antihyperglycemic (S)-α-Aryloxy-β-phenylpropionic Acid Using a Bifunctional Asymmetric Catalyst

Makoto Takamura; Hiroaki Yanagisawa; Motomu Kanai; Masakatsu Shibasaki

doi:10.1248/cpb.50.1118

Notes

Efficient Synthesis of Antihyperglycemic (S)-α-Aryloxy-β-phenylpropionic Acid Using a Bifunctional Asymmetric Catalyst

Makoto Takamura, Hiroaki Yanagisawa, Motomu Kanai, Masakatsu Shibasaki

Author information

Keywords: asymmetric catalysis, antihyperglycemic agent, PPARγ, bifunctional catalyst

JOURNAL FREE ACCESS

2002 Volume 50 Issue 8 Pages 1118-1121

DOI https://doi.org/10.1248/cpb.50.1118

Details

Abstract

Antihyperglycemic (S)-α-aryloxy-β-phenylpropionic acid was prepared using catalytic asymmetric cyanosilylation as a key reaction to construct α-oxycarboxylic acid moiety.

Corresponding author

Register with J-STAGE for free!