Six New Andrographolide Metabolites in Rats

Xiangjiu He; Jiankuan Li; Hao Gao; Feng Qiu; Xiangmin Cui; Xinsheng Yao

doi:10.1248/cpb.51.586

Notes

Six New Andrographolide Metabolites in Rats

Xiangjiu He, Jiankuan Li, Hao Gao, Feng Qiu, Xiangmin Cui, Xinsheng Yao

著者情報

キーワード: andrographolide, metabolite in rats, sulfate ester, 14-deoxy-12(R)-sulfo andrographolide 3-sulfate, 14-deoxy-12(S)-sulfo andrographolide 3-sulfate, 14-sulfo isoandrographolide 3-sulfate

ジャーナルフリー

2003 年 51 巻 5 号 p. 586-589

DOI https://doi.org/10.1248/cpb.51.586

詳細

抄録

Six new andrographolide metabolites M-5—M-10 were isolated from rat urine, feces, and the contents of the small intestine. Three (M-5—M-7) as sulfate ester compounds were identified as new compounds. The structures of these six metabolites were determined to be 14-deoxy-12(R)-sulfo andrographolide 3-sulfate (M-5), 14-deoxy-12(S)-sulfo andrographolide 3-sulfate (M-6), 14-sulfo isoandrographolide 3-sulfate (M-7), 14-deoxy-11,12-didehydroandrographolide (M-8), isoandrographolide (M-9), and 14-deoxy andrographolide (M-10), respectively, based on chemical evidence and spectroscopic analysis.

責任著者(Corresponding author)

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