New Sesquiterpene Hydroperoxides with Trypanocidal Activity from Pogostemon cablin

Fumiyuki Kiuchi; Kenji Matsuo; Michiho Ito; Tran Kim Qui; Gisho Honda

doi:10.1248/cpb.52.1495

Notes

New Sesquiterpene Hydroperoxides with Trypanocidal Activity from Pogostemon cablin

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

著者情報

キーワード: Pogostemon cablin, Labiatae, sesquiterpene hydroperoxide, trypanocidal constitutent, Trypanosoma cruzi

ジャーナルフリー

2004 年 52 巻 12 号 p. 1495-1496

DOI https://doi.org/10.1248/cpb.52.1495

詳細

抄録

Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1—3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1—3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）