Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative

Sayaka Matsushita; Yoshihiro Yanai; Asami Fusyuku; Yukio Fujiwara; Tsuyoshi Ikeda; Masateru Ono; Chunguang Han; Makoto Ojika; Toshihiro Nohara

doi:10.1248/cpb.55.1077

Notes

Efficient Conversion of Tomatidine into Neuritogenic Pregnane Derivative

Sayaka Matsushita, Yoshihiro Yanai, Asami Fusyuku, Yukio Fujiwara, Tsuyoshi Ikeda, Masateru Ono, Chunguang Han, Makoto Ojika, Toshihiro Nohara

著者情報

キーワード: tomatidine, acetylation, δ²⁰⁽²²⁾-pseudo compound, ozonolysis, pregnane derivative, neuritogenic activity

ジャーナルフリー

2007 年 55 巻 7 号 p. 1077-1078

DOI https://doi.org/10.1248/cpb.55.1077

詳細

抄録

Moderate acetylation of tomatidine with anhydrous acetic acid and pyridine for 20 h at r.t., followed by pseudomerization in ice-water, gave a δ²⁰⁽²²⁾-pseudo compound, which was then subjected to ozonolysis to provide a pregnane derivative in a total 54% yield showing neuritogenic and NGF-enhancing activities.

責任著者(Corresponding author)

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