Reinvestigation of the Synthesis of Isoliquiritigenin: Application of Horner–Wadsworth–Emmons Reaction and Claisen–Schmidt Condensation

Shigeki Sano; Yoshinori Okubo; Atsushi Handa; Michiyasu Nakao; Syuji Kitaike; Yoshimitsu Nagao; Hisao Kakegawa

doi:10.1248/cpb.59.885

Notes

Reinvestigation of the Synthesis of Isoliquiritigenin: Application of Horner–Wadsworth–Emmons Reaction and Claisen–Schmidt Condensation

Shigeki Sano, Yoshinori Okubo, Atsushi Handa, Michiyasu Nakao, Syuji Kitaike, Yoshimitsu Nagao, Hisao Kakegawa

著者情報

キーワード: isoliquiritigenin, chalcone, Horner–Wadsworth–Emmons reaction, Claisen–Schmidt condensation, cis–trans isomerization

ジャーナルフリー

2011 年 59 巻 7 号 p. 885-888

DOI https://doi.org/10.1248/cpb.59.885

詳細

抄録

Isoliquiritigenin [ILG, (E)-1] was readily prepared via the Horner–Wadsworth–Emmons reactions using β-ketophosphonates 5a, b. An improved protocol for the synthesis of (E)-1 via the Claisen–Schmidt condensation was also presented.

責任著者(Corresponding author)

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