Pseuduvarines A and B, Two New Cytotoxic Dioxoaporphine Alkaloids from Pseuduvaria rugosa

Hairin Taha; A. Hamid A. Hadi; Noraziah Nordin; Ibrahim A. Najmuldeen; Khalit Mohamad; Osamu Shirota; Alfarius E. Nugroho; Wong Chin Piow; Toshio Kaneda; Hiroshi Morita

doi:10.1248/cpb.59.896

Notes

Pseuduvarines A and B, Two New Cytotoxic Dioxoaporphine Alkaloids from Pseuduvaria rugosa

Hairin Taha, A. Hamid A. Hadi, Noraziah Nordin, Ibrahim A. Najmuldeen, Khalit Mohamad, Osamu Shirota, Alfarius E. Nugroho, Wong Chin Piow, Toshio Kaneda, Hiroshi Morita

著者情報

キーワード: pseuduvarine A, pseuduvarine B, dioxoaporphine, Pseuduvaria rugosa, cytotoxic activity

ジャーナルフリー

2011 年 59 巻 7 号 p. 896-897

DOI https://doi.org/10.1248/cpb.59.896

詳細

抄録

Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC₅₀, 0.9, 21.7, and >50.0 μM, respectively, 2: IC₅₀ >50.0, 15.7, and 12.4 μM, respectively).

責任著者(Corresponding author)

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