Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Synthesis of Nitriles via the Iodine-Mediated Dehydrosulfurization of Thioamides
Yuki MurataHitomi IwasaMio MatsumuraShuji Yasuike
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2020 年 68 巻 7 号 p. 679-681

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A simple general method for the synthesis of nitriles using the inexpensive and easy to handle iodine (I2) is described herein. The reaction of thioamides with I2 in the presence of triethylamine at room temperature under aerobic conditions afforded various nitriles bearing aryl, vinyl, and alkyl groups in good-to-excellent yields. This method was also effective for conversion from thioureas to cyanamides.

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© 2020 The Pharmaceutical Society of Japan
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