Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Reviews
Development of Transition-Metal-Catalysed Cross-Coupling Reactions through Ammonium C–N Bond Cleavage
Chao Wang
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2020 Volume 68 Issue 8 Pages 683-693

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Abstract

In this review, we summarize our recent progress on functionalization of the ammonium C–N bond through a transition-metal-catalysed cross-coupling process. By synergistic utilization of computational and experimental methods, we have successfully developed several new C–N bond cleavage protocols and established new reaction mechanisms. These findings provide new possibilities for transforming naturally abundant chemicals into useful functional molecules in an efficient and selective manner.

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© 2020 The Pharmaceutical Society of Japan
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