Studies on Coenzyme Analogs. XIV. A New Phosphorylating Agent, Morpholinophosphorodichloridate.
1963 年 11 巻 4 号 p. 435-440
詳細
1963 年 11 巻 4 号 p. 435-440
A new phosphorylating agent, morpholinophosphorodichloridate was synthesized from phosphorylchloride and morpholine. The reagent was used successfully for the synthesis of adenosine 5'-monophosphate and 6-dimethylamino-9-β-D-ribofuranosylpurine 5'-monophosphate. Starting from 2', 3'-di-O-acetyladenosine, adenosine 5'-di- and triphosphate were synthesized by phosphorylation with this reagent followed by the reaction with inorganic phosphate or pyrophosphate in fairy good overall yield.
