Studies on the Metabolism of Sulfadimethoxine. III. Kinetics of Sulfadimethoxine Metabolism.

Abstract

The kinetic constants defining the rate of sulfadimethoxine metabolism were calculated using analog computer. Observed values were in good agreement with theoretical values calculated by an equation developed to account for the various processes involved in the transformation and excretion of sulfadimethoxine. The theoretical curve for the amount of unchanged sulfadimethoxine remained in the body was obtained. From this curve, the half life of unchanged sulfadimethoxine in the body was decided to be 25 hours.