1967 Volume 15 Issue 9 Pages 1287-1293
Stabilities, absorption and excretion profiles, and biotransformations of the ω-substituted alkyl-PAS were investigated. The observations presented here support the conclusion that derivatives are stable in gastro-intestinal tract and absorbed more readily than that parent compound. Derivatives with long alkyl chain have characteristics of sustained release and can maintain high level in body fluid for long period. These derivatives are metabolized to the same extent regardless of their differences of the structure.