Stereochemistry in Solution. III. Stereoselectivity in N-Quaternization and N-Oxygenation of α-Substituted Piperidines.

Abstract

Stereoselectivities in salt formation, N-methylation, N-ethylation, and N-oxygenation of α-substituted piperidines were examined in connection with the free energy-difference between the reaction intermediates in the axial and equatorial approaches of the reagent.