Synthesis and Structure of 4-Substituted Decahydroisoquinoline Derivatives

Abstract

Four possible racemates of 4-hydroxymethyldecahydroisoquinolines, hitherto unknown in the literature, were synthesized and their stereochemistry was specified and characterized. Hydrochloride salts of their benzoylesters were also prepared and their local anesthetic activity was tested, but none was proved to be useful.