Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies of Tenuazonic Acid Analogs. I. Synthesis of 5-Substituted 3-(1'-Anilinoethylidene) pyrrolidine-2, 4-dione
HIDETAKA YUKIYOKO KAIZUSEISUKE YOSHIDASADAO HIGUCHISUSUMU HONDAKIYOSHI TAKIURA
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1971 年 19 巻 8 号 p. 1664-1668

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Derivatives of tenuazonic acid, 3-acetyl-5-sec-butyltetramic acid, were synthesized. 5-Substituted 3-acetyl tetramic acids were condensed with primary aromatic amines refluxing in alcohol. The structure of the condensation products were determined as 5-substituted 3-(1'-anilinoethylidene) pyrrolidine-2, 4-dione. The stability of the one of the condensation products was investigated, and it was found to be stable in acidic and neutral, but unstable in alkaline medium.
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© The Pharmaceutical Society of Japan
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