Pharmacological Studies of Troponoids. IV. Antipyretic Analgesic, and Anti-inflammatory Activities of Aminotroponoids

Abstract

The analgesic, anti-inflammatory and antipyretic activities of six aminotroponoidcompounds were investigated.
Analgesic activities of 5-aminotropolone (I) and 2-aminotropone (II) are found to be equipotent to that of aminopyrine.
All the test compounds do not inhibit the development of the erythema induced by ultraviolet irradiation, but I and II show the strong inhibition (70-80%) of the enhancement of capillary permeability induced by acetic acid.
Compounds, I and II produce marked hypothermia in mice, rats, and guinea-pigs, and I and II show the antipyretic activities as same as aminopyrine.
The acute toxic symptoms of most of the test compounds are generally the extremities ataxia and the respiratory paralysis.