Abstract
The alkaline decomposition of 2, 3, 5, io-tetrahydro-lH-pyrazolo [1, 2-b] phthalazin-s-one methiodide (VIIa), its methyl derivatives (VIIb-d), and 1, 2, 3, 4, 6, 11-hexahydropyridazo-[1, 2-b] phthalazin-6-one methiodide (XIV) was examined. Compounds VIIa-d afforded 1-methyl-1, 3, 4, iob-tetrahydro-2H-pyrimido [2, 1-a] isoindol-6-ones (VI IIa-d), and XIV afforded 1-methyl-1, 2, 3, 4, 5, 11b-hexahydro-7H-1, 3-diazepino [2, 1-a] isoindol-7-one (XV). In all cases the Stevens-type rearrangement involving lactam nitrogen migration from nitrogen to carbon occurred. Their configuration and conformation were discussed.
