Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Formic Acid Reduction. XV. Reaction of N-Methyl and N-Formyl Derivatives of p-Phenylenediamine with Formates. N-Methylation of Formanilides
関屋 実高山 修一伊藤 敬一鈴木 次郎鈴木 邦夫寺尾 良保
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1972 年 20 巻 12 号 p. 2661-2668

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Conversion of varied N-methyl and N-formyl derivatives of p-phenylenediamine to other kinds of analogous compounds with increase and decrease of N-methyl has been found to occur on heating at 175-180° with the high-boiling liquid formates composed of formic acid and trialkylamine. From investigation on this reaction the formate reagents have been introduced to affect N-methylation of formanilides in a course entirely different from the known demethylation by the same reagents.
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© The Pharmaceutical Society of Japan
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