Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Heterocyclic Compounds. XVIII. Synthesis of Furo [2, 3-d] pyridazine Derivatives. (6). Nitration of 4-Oxo-7-chloro-4, 5-dihydrofuro [2, 3-d] pyridazine
吉名 重多賀前波 勇
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1972 年 20 巻 5 号 p. 936-939

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Nitration of 4-oxo-7-chloro-4, 5-dihydrofuro [2, 3-d] pyridazine (V) with 96% sulfuric acid and fuming nitric acid gave 2-nitro-4-oxo-7-chloro-4, 5-dihydrofuro [2, 3-d] pyridazine (VII) and trans-2-nitro-3-hydroxy-4-oxo-7-chloro-2, 3, 4, 5-tetrahydrofuro [2, 3-d]-pyridazine (VIII). Nitration of V with 75% sulfuric acid and fuming nitric acid gave three products ; VII, VIII and cis-2-nitro-3-hydroxy-4-oxo-7-chloro-2, 3, 4, 5-tetrahydrofuro [2, 3-d] pyridazine (IX). The structure assignment of this trans-cis isomers were described.
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