Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XVIII. Reaction of 1-Methyl-2 (1H)-quinolone with Phosphoryl Chloride and N, N-Dimethylaniline
富沢 宏鈴木 敏之沢田 一本郷 弘司藤田 礼子加藤 秀樹王 昭雄
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1973 年 21 巻 12 号 p. 2602-2606

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Reaction of 1-methyl-2 (1H)-quinolone with phosphoryl chloride and dimethylaniline was successfully carried out. The two products, 2-[4'-(dimethylamino) phenyl] quinolinium chloride (V) and 2-[4'-(dimethylamino) phenyl] quinoline (VI), were obtained in good yield, 76.2% for V and 2.6% for VI, which can be change the ratio between those two products of the reaction condition changed. The structure of products were confirmed by the corresponding Grignard reactions. The same reaction of 1-methyl-2 (1H)-thioquinolone was attempted with low yield and only one product (VI).
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© The Pharmaceutical Society of Japan
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