Utilization of Protopine and Related Alkaloids. VIII. Synthesis of an Analogue of Alkaloid Corynoline

Abstract

An analogue of corynoline, trans-11-hydroxy-10b-methyl-cis-4b, 5, 6, 10b, 11, 12-hexahydrochelerythrine, is stereoselectively synthesized from the ψ-cyanide 7 which has been derived from berberine chloride. This synthetic procedure is also connected with α-allo-cryptopine by its transformation to berberine chloride.