抄録
Inclusion of antiinflammatory drugs fenamates within the cavity of β-cyclodextrin in aqueous solution was confirmed by circular dichroism, ultraviolet absorption, and nuclear magnetic resonance spectroscopies. Solubility and spectral changes were quantitatively investigated and stoichiometric ratio, which was found to be 1 : 1, formation constants, and thermodvnamic parameters were obtained for complex formation of β-cyclodextrin with fenamates. Hydrophobic and steric factors were reflected in the values of formation constants. Isoequilibrium relationship between ΔH and ΔS values were observed having a compensation temperature of 284°K. From these evidences mode of inclusion was discussed.
